If you defrosted the bottle of E3Live in your refrigerator or in a cool bowl of water, and it hasn't been thawed for more than a few hours, it should be fine. Just pour off the portion for the week that you need, then refreeze the rest. Alternately you can pour off your week's worth, then make single-serving E3Live ice cubes by pouring into ice cube trays that have resealable lids (to keep freezer odors out). Add the single serving cube to your water or juice as your daily dose of E3Live.
If the E3Live has thawed out in a very hot room, has been out for many hours, has thawed outside in the sun, or some similar undesirable condition - check it for color and smell. If it spoils, it will turn a muddy brown color and have a rancid smell that will tell you that it has spoiled. If this happens - you can always mix it with water for an awesome plant fertilizer!